The Difference Is drsp®
What is drsp?
All combination hormone therapies (HTs) contain an estrogen and a progestin. Estrogen is used to help relieve menopausal symptoms, like hot flashes, night sweats and vaginal dryness. However, in women with a uterus, estrogen alone can increase the risk of uterine cancer. The progestin in a combination HT helps reduce that risk.
The progestin in ANGELIQ® tablets (drospirenone/estradiol), is different from the progestin found in other HTs. It’s called drsp or drospirenone (pronounced dros-peer-eh-known).
While many synthetic progestins are made from the male hormone, testosterone, drsp is derived from spironolactone. Unlike the progestins found in other HTs, spironolactone most closely resembles and acts like the hormone progesterone made by your body.
In fact, drsp is the most preferred progestin of OB/GYNs.* Ask your healthcare professional about the unique properties of drsp and what they may mean for you.
* In a survey of OB/GYNs, drsp was the preferred progestin in oral contraceptive use.
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What important information should you know about ANGELIQ® tablets (drospirenone / estradiol) 0.5mg / 1mg?
ANGELIQ contains a different kind of hormone, drsp®, which may increase potassium. Therefore you should not take ANGELIQ if you have kidney, liver, or adrenal disease. Be sure to talk to your doctor about taking ANGELIQ if you regularly take other medications that can increase your potassium levels. These can include: NSAIDs-ibuprofen (Motrin®, Advil®), naproxen (Naprosyn®, Aleve®, and others) when taken long-term and daily for arthritis or other diseases or conditions, potassium-sparing diuretics (spironolactone and others), potassium supplementation, ACE inhibitors (Capoten®, Vasotec®, Zestril®, and others), angiotensin-II receptor antagonists (Cozaar®, Diovan®, Avapro®, and others), and heparin.
Do not use estrogens with or without progestins to prevent heart disease, heart attack or strokes.
Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer and blood clots.
The most commonly reported side effects are irregular vaginal bleeding, breast pain and headaches.
Do not use ANGELIQ if you have had your uterus removed (hysterectomy), have unusual vaginal bleeding, have or have had a stroke or heart attack in the past year, currently have or have had blood clots, liver problems, or are allergic to ANGELIQ or any of its ingredients.
Estrogens with or without progestins should be used at the lowest effective doses and only for as long as menopausal symptoms persist. You and your healthcare provider should talk regularly about whether or not you still require treatment with ANGELIQ.
Motrin is the registered trademark of Johnson & Johnson Company; Advil is the registered trademark of Wyeth Consumer Healthcare, Inc.; Aleve is the registered trademark of Bayer HealthCare LLC; Naprosyn is the registered trademark of Hoffmann-La Roche Inc.; Capoten is the registered trademark of Par Pharmaceutical, Inc.; Vasotec is the registered trademark of Merck & Company, Inc.; Zestril is the registered trademark of AstraZeneca Pharmaceutical LP; Diovan is the registered trademark of Novartis Corporation; Avapro is the registered trademark of Sanofi-Aventis US, LP; Cozaar is the registered trademark of E.I. du Pont de Nemours and Company.