Using ANGELIQ

Fast relief may be a once-a-day tablet away
ANGELIQ tablets (drospirenone/estradiol) may provide fast relief from moderate to severe menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. In just 4 weeks, symptoms may be reduced by close to 70% by the estrogen in ANGELIQ.¹

To use ANGELIQ most effectively, it is important to take one ANGELIQ tablet a day as part of your regular routine:

• Take one ANGELIQ tablet at the same time each day
• Pair taking ANGELIQ with an everyday activity such as brushing your teeth or going to sleep
• Keep your pill pack in a place where you can see it as a reminder. Make sure it's out of the reach of children and pets
• If you stay overnight or travel
  • Be sure to put ANGELIQ on your packing list
  • Make sure to bring enough tablets to keep you covered while you are away
  • When flying, pack your ANGELIQ in your carry-on luggage
• Plan ahead. Don't wait until you take the last tablet in your pack to refill your prescription

ANGELIQ should be taken for the shortest duration of time at the lowest dose. Talk with your healthcare provider each year about whether you should remain on ANGELIQ. Do not stop taking ANGELIQ without first talking with your healthcare provider. ANGELIQ is for women with a uterus. If you have had your uterus removed (hysterectomy) and are suffering from moderate to severe menopausal symptoms, ask your healthcare provider about alternative options, including a once-a-week estrogen patch.

IMPORTANT SAFETY INFORMATION

What is ANGELIQ used for?

ANGELIQ is used after menopause to:

• Reduce moderate to severe hot flashes
• Treat moderate to severe dryness, itching, and burning in or around the vagina
  • When prescribing solely for vaginal dryness, other treatments should be considered

Who should not use ANGELIQ?

Do not use ANGELIQ if you have had your uterus removed (hysterectomy). ANGELIQ contains a progestin to decrease the chances of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not use ANGELIQ.

Do not start taking ANGELIQ if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, have kidney disease, liver disease, or disease of your adrenal glands, are allergic to ANGELIQ or any of its ingredients, or think you may be pregnant.

What are the warnings of less common but serious side effects of ANGELIQ?

Warnings of less common but serious side effects of ANGELIQ include breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, and vomiting. Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

What are common side effects of ANGELIQ?

Common side effects of ANGELIQ include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the full prescribing information.