About ANGELIQ

The way you experience menopause is personal to you
We know that you probably have questions and concerns about menopause symptoms such as hot flashes, night sweats and vaginal dryness, and how to treat them. We think ANGELIQ^® tablets (drospirenone/estradiol) may have the answers you've been looking for.

ANGELIQ^® is a unique combination of hormones for women going through natural menopause.

Estrogens with or without the progestins, including ANGELIQ, should not be used for the prevention of cardiovascular disease or dementia.

Fast relief for hot flashes, night sweats and vaginal dryness
ANGELIQ was developed for women going through menopause naturally, meaning they still have their ovaries and uterus.

ANGELIQ is a once-a-day pill FDA approved for fast relief of moderate to severe hot flashes, night sweats, and vaginal dryness.

In just 4 weeks, these symptoms were reduced by close to 70%, and by 12 weeks, symptoms were reduced by over 90% by the estrogen in ANGELIQ.¹

In clinical trials, the hormones in ANGELIQ have been proven to help women find relief from these common symptoms of menopause.

Adverse events most commonly observed in clinical trials were headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

A unique combination

ANGELIQ is the only hormone therapy with a unique combination of hormones for treating menopause:

• Estradiol—a plant-based estrogen similar in makeup to what your body makes naturally; proven in hormone therapy for more than 10 years
• Drospirenone—drsp^®—the same progestin used in the #1-branded oral contraceptive; ANGELIQ is the only hormone therapy with drsp
• Estrogens with or without the progestins, including ANGELIQ, should not be used for the prevention of cardiovascular disease or dementia

It's the right combination for relief of your menopausal symptoms.

IMPORTANT SAFETY INFORMATION

What is ANGELIQ used for?

ANGELIQ is used after menopause to:

• Reduce moderate to severe hot flashes
• Treat moderate to severe dryness, itching, and burning in or around the vagina
  • When prescribing solely for vaginal dryness, other treatments should be considered

Who should not use ANGELIQ?

Do not use ANGELIQ if you have had your uterus removed (hysterectomy). ANGELIQ contains a progestin to decrease the chances of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not use ANGELIQ.

Do not start taking ANGELIQ if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, have kidney disease, liver disease, or disease of your adrenal glands, are allergic to ANGELIQ or any of its ingredients, or think you may be pregnant.

What are the warnings of less common but serious side effects of ANGELIQ?

Warnings of less common but serious side effects of ANGELIQ include breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, and vomiting. Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

What are common side effects of ANGELIQ?

Common side effects of ANGELIQ include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the full prescribing information.