Discussion Guide

Talking With Your Healthcare Provider
Before starting any new medication, it is important to understand the benefits and risks of all your treatment options.

Talk openly with your healthcare provider about your personal and family medical history, as well as your diet and current exercise routine. This information will help you and your healthcare provider determine what treatment options may be right for you.

To get the most out of your next medical appointment, think about what you want to know in advance. The following list of questions is a great place to start:

1. Am I going through menopause naturally?
2. Are my menopausal symptoms considered moderate to severe?
3. What is hormone therapy (HT)?
4. What hormone therapies are available to treat menopausal symptoms?
5. How is ANGELIQ^® tablets (drospirenone/estradiol) with drospirenone (drsp^®) and estradiol different from other hormone therapies?
6. How do I know if ANGELIQ is right for me?
7. Should I be concerned about taking hormone therapy?
8. Are there any lifestyle changes I can make to help me feel more comfortable during menopause?

ANGELIQ should be used by women with a uterus experiencing natural menopause. Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attack, strokes, breast cancer, and blood clots. Using estrogens with or without progestins may increase your risk of dementia. You and your healthcare provider should talk regularly about whether you still need treatment with ANGELIQ.

...and take it with you to your next appointment with your healthcare provider.

IMPORTANT SAFETY INFORMATION

What is ANGELIQ used for?

ANGELIQ is used after menopause to:

• Reduce moderate to severe hot flashes
• Treat moderate to severe dryness, itching, and burning in or around the vagina
  • When prescribing solely for vaginal dryness, other treatments should be considered

Who should not use ANGELIQ?

Do not use ANGELIQ if you have had your uterus removed (hysterectomy). ANGELIQ contains a progestin to decrease the chances of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not use ANGELIQ.

Do not start taking ANGELIQ if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, have kidney disease, liver disease, or disease of your adrenal glands, are allergic to ANGELIQ or any of its ingredients, or think you may be pregnant.

What are the warnings of less common but serious side effects of ANGELIQ?

Warnings of less common but serious side effects of ANGELIQ include breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, and vomiting. Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

What are common side effects of ANGELIQ?

Common side effects of ANGELIQ include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the full prescribing information.