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ABOUT ANGELIQ

A Unique Combination

Is ANGELIQ Right For Me

How Do I Get ANGELIQ?

Discussion Guide

USING ANGELIQ

What to Expect

ABOUT MENOPAUSE

Understanding Your Symptoms

Treatment Options

Healthy Lifestyle Changes

Assess Your Symptoms

ABOUT HORMONE THERAPY

Hormone Therapy Today

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IMPORTANT
SAFETY
INFORMATION

A Unique Combination

All combination hormone therapies (HTs) contain an estrogen and a progestin. Estrogen is used to help relieve menopausal symptoms, like hot flashes, night sweats, and vaginal dryness. However, in women with a uterus, estrogen alone can increase the risk of uterine cancer. The progestin in a combination HT may help to reduce this risk.

ANGELIQ^® tablets (drospirenone/estradiol) has a unique combination of hormones for treating menopause.

Plant-based estrogen: estradiol
The estrogen in ANGELIQ is estradiol, a plant-based estrogen similar in makeup to what your body makes naturally. Estradiol has been proven in hormone therapy for more than 10 years.

Progestin: drsp^®
The progestin in ANGELIQ is different from the progestin found in other HTs. It's called drsp, or drospirenone (pronounced dros-peer-eh-known), and is the same progestin used in the #1-dispensed oral contraceptive.

ANGELIQ is the only hormone therapy with drsp.

Estrogens with or without the progestins, including ANGELIQ, should not be used for the prevention of cardiovascular disease or dementia.

Drsp may increase potassium or lower the sodium in your blood. You should not take ANGELIQ if you have kidney, liver, or adrenal disease because these conditions may also increase the potassium in your blood.

IMPORTANT SAFETY INFORMATION

What is ANGELIQ used for?

ANGELIQ is used after menopause to:

Reduce moderate to severe hot flashes
Treat moderate to severe dryness, itching, and burning in or around the vagina
- When prescribing solely for vaginal dryness, other treatments should be considered

What is the most important information I should know about ANGELIQ (a combination of estrogen and a progestin)?

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.

Using estrogens with or without progestins may increase your chances of getting heart attack, strokes, breast cancer, and blood clots. Using estrogens with or without progestins may increase your risk of dementia. You and your healthcare provider should talk regularly about whether you still need treatment with ANGELIQ.

Who should not use ANGELIQ?

Do not use ANGELIQ if you have had your uterus removed (hysterectomy). ANGELIQ contains a progestin to decrease the chances of getting cancer of the uterus. If you do not have a uterus, you do not need a progestin and you should not use ANGELIQ.

Do not start taking ANGELIQ if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, have kidney disease, liver disease, or disease of your adrenal glands, are allergic to ANGELIQ or any of its ingredients, or think you may be pregnant.

What are the warnings of less common but serious side effects of ANGELIQ?

Warnings of less common but serious side effects of ANGELIQ include breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, and vomiting. Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

What are common side effects of ANGELIQ?

Common side effects of ANGELIQ include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For important risk and use information, please see the full prescribing information.

Is ANGELIQ right for you?
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